Synthetic Route of 30529-70-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30529-70-5, name is 2-Chloro-6-methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
Methyl iodide (10.33 ml) was added to a stirred suspension of 2-chloro-6-nicotinic acid (22.8 g) and potassium carbonate (36.8 g) in DMF (190 ml), under an inert atmosphere at ambient temperature. After stirring vigorously for 16 hours the suspension was filtered and the solid residue washed with 10% methanol/dichloromethane (100 ml). The filtrate was then concentrated under reduced pressure and the residue diluted with water (250 ml), extracted with dichloromethane (3¡Á150 ml) and the combined extracts dried and concentrated under reduced pressure. Purification by bulb to bulb distillation (140 C. 0.05 mmHg) gave methyl 2-chloro-6-nicotinoate as a white solid (23.6 g). 1H NMR (CDCl3) delta 2.50 (3H, s), 3.85 (3H, s), 7.10 (1H, d), 8.00 (1H, d). MS(MH+) 186.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30529-70-5, 2-Chloro-6-methylnicotinic acid.
Reference:
Patent; AstraZeneca UK Limited; Zeneca-Pharma SA; US6342765; (2002); B1;,
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