Application of 71670-70-7 , The common heterocyclic compound, 71670-70-7, name is 2-(Chloromethyl)-5-methylpyridine hydrochloride, molecular formula is C7H9Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The compound of Reference Example 48 (0.063g, 0.253mmol), 2- (chloromethyl) -5-methyl-pyridine monohydrochloride (0.050g, 0.281mmol), tetrabutylammonium chloride (0.008g, 0.0248 mmol), 50% aqueous potassium carbonate (0.280 g of) and tetrahydrofuran (3.0mL) the mixture was stirred overnight performed at 80 . After the reaction, diluted with water, and extracted with ethyl acetate. And the organic layers were combined, dried over sodium sulfate, filtered, concentrated, and the use of silica gel chromatography (chloroform: methanol = 9: 1) and the residue was purified to obtain the title compound (0.058g, 64%).
The synthetic route of 71670-70-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; YOSHINAGA, HIDEFUMI; URUNO, YOSHIHARU; SAWAMURA, KIYOTO; GOTO, NANA; IKUMA, YOHEI; (165 pag.)TW2016/5858; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem