Introduction of a new synthetic route about 2-Fluoro-3-nitro-5-methylpyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19346-44-2, 2-Fluoro-3-nitro-5-methylpyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 19346-44-2, 2-Fluoro-3-nitro-5-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Fluoro-3-nitro-5-methylpyridine, blongs to pyridine-derivatives compound. Safety of 2-Fluoro-3-nitro-5-methylpyridine

3-Amino-2-fluoro-5-methylpyridine was prepared analogously from 2-fluoro-5-methyl-3-nitropyridine. This compound was obtained in 89 percent yield as white solid melting at 27-28.5 C. Elemental Analysis C6 H7 FN2 Calc.: %C, 57.1; %H, 5.59; %N, 22.2 Found: %C, 56.9, %H, 5.65; %N, 22.6 1 H NMR CDCl3: 7.2 (d, 1H); 6.8 (d, 1H); 3.7 (br, 2H); 2.1 (s, 3H); 13 C NMR CDCl3: 151.8 (d, J=229); 134.5 (d, J=12.6); 132.2 (d, J=3.9); 129.9 (d, J=28.7); 125.8 (d, J=5.3), 17.8.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19346-44-2, 2-Fluoro-3-nitro-5-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; DowElanco; US5461161; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem