Synthetic Route of 582303-10-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of methyl ( 6-hydroxy-4-vinyl-l- benzothiophen-3-yl) acetate (351 mg) and THF (dry) (3 mL) were added (2, 6-dimethylpyridin-3-yl) methanol (233 mg) , ADDP (535 mg) and tri-n-butylphosphine (0.523 mL) at room temperature. The precipitate was removed by filtration, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane ) to give the title compound (459 mg) . XH NMR (300 MHz, CDC13) delta 2.54 (3H, s) , 2.58 (3H, s) , 3.68-3.72 (3H, m) , 3.98 (2H, s) , 5.07 (2H, s) , 5.35-5.43 (1H, m) , 5.51- 5.61 (1H, m) , 6.99-7.06 (2H,m) , 7.12 (1H, s) , 7.28-7.41 (2H, m) , 7.61 (1H, d, J = 7.9 Hz) .
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei; WO2013/125732; (2013); A1;,
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