Related Products of 573675-27-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.573675-27-1, name is 3-Amino-5-bromopicolinonitrile, molecular formula is C6H4BrN3, molecular weight is 198.02, as common compound, the synthetic route is as follows.
To a solution of 3-amino-5-bromopicolinonitrile (300 mg, 1.51 mmol) in 1,2-dichloroethane (5 mL) was added w-CPBA (1.23 g, 6.06 mmol) at 0 C. The reaction mixture was stirred 0 C for 1 h and then 80 C for 20 h. The reaction quenched with saturated aqueous Na2S203 (10 mL) and then extracted with DCM (10 mL x 3). The combined organics were dried over anhydrous Na2S04 and concentrated. The residue was purified by silica gel chromatography (20%-80% EtOAc /petroleum ether) to give the title compound. MS: 214, 216 (M+l).
Statistics shows that 573675-27-1 is playing an increasingly important role. we look forward to future research findings about 3-Amino-5-bromopicolinonitrile.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; ACTON, John, J., III; BAO, Jianming; DENG, Qiaolin; EGBERTSON, Melissa; FERGUSON, Ronald, III; GAO, Xiaolei; HARRISON, Scott Timothy; KNOWLES, Sandra, L.; LI, Chunsing; LO, Michael Man-Chu; MAZZOLA, Robert, D., Jr.; MENG, Zhaoyang; NA, Meng; RUDD, Michael, T.; SELYUTIN, Oleg, B.; TELLERS, David, M.; TONG, Ling; ZHANG, Fengqi; (195 pag.)WO2019/5587; (2019); A1;,
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