Electric Literature of 15862-50-7, Adding some certain compound to certain chemical reactions, such as: 15862-50-7, name is 3-Bromo-2-methoxy-5-nitropyridine,molecular formula is C6H5BrN2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15862-50-7.
Step 1) A mixture of 3-bromo-2-methoxy-5-nitropyridine (Intermediate 51, 25 g, 107.3 mmol), tributyl(l-ethoxyvinyl)stannane (43.5 mL, 130.3 mmol) and tetrakis(triphenylphosphine)palladium(0) (8.68 g, 7.51 mmol) in anhydrous DMAC (100 mL) was purged with N2 for 30 min and then heated at 120C for 3 h. After cooling to rt the mixture was poured into 1M aqueous HC1 (500 mL). The mixture was stirred overnight before saturated aqueous potassium sodium tartrate solution (800 mL) was added and the mixture was extracted with EtOAc (2 x 300 mL). The combined organic phases were dried (MgS04), filtered and concentrated in vacuo. Purification by gradient flash column chromatography eluting with 0-30% EtOAc in z’sohexane yielded a yellow solid, which was slurried in diethyl ether and filtered to afford l-(2-methoxy-5-nitropyridin-3-yl)ethanone (3.38 g, 17.2 mmol) as white solid. LCMS (Method 3): m/z 197 (ES+), at 1.09 min. (0387) 1H NMR: (400 MHz, DMSO-i) delta: 2.62 (s, 3H), 4.13 (s, 3H), 8.66 (d, J=2.8, 1H), 9.24 (d, J=2.8, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HEPTARES THERAPEUTICS LIMITED; CHRISTOPHER, John Andrew; BUCKNELL, Sarah Joanne; CONGREVE, Miles Stuart; TEHAN, Benjamin Gerald; NONOO, Rebecca Helen; BROWN, Giles Albert; SWAIN, Nigel Alan; MILLS, Mark; (111 pag.)WO2019/86902; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem