Reference of 1133879-69-2, Adding some certain compound to certain chemical reactions, such as: 1133879-69-2, name is 3-Fluoro-5-vinylpyridine,molecular formula is C7H6FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1133879-69-2.
A mixture of carboline 2 (1 mmol), vinylpyridine 3a (1 mmol), CsF (0.1 g), hydroquinone(0.02 g), and DMSO (1.5 mL) was heated with stirring for 6 h at 150-160 C and then concentrated in vacuo (3 Torr). The residue was extracted with CH2Cl2, and the solution was concentrated. The product was isolated by chromatography on silica gel(260 mesh) using MeOH-CHCl3, 1 : 10, as the eluent. Yield 2.6 g (80%). M.p. 103-104 C. 1H NMR (CDCl3), delta: 2.44 (s, 3 H,Me); 2.49-2.56 (m, 5 H, CH2 and MeN); 2.72 (t, 2 H, CH2, 3JH,H = 6.1 Hz); 3.01 (t, 2 H, CH2, 3JH,H = 6.0 Hz); 3.65 (s, 2 H, CH2); 4.20 (t, 2 H, CH2, 3JH,H = 6.0 Hz); 6.88 (dt, 1 H, CHPy, 3JH,F = 9.1 Hz, 4JH,H = 1.9 Hz); 6.98 (d, 1 H, CHInd, 3JH,H = 8.4 Hz); 7.10 (d, 1 H, CHInd, 3JH,H = 8.4 Hz); 7.20 (s, 1 H, CHInd); 8.11 (t, 1 H, CHPy, 4JH,H = 1.9 Hz); 8.32 (d, 1 H, CHPy, 4JH,H = 1.9 Hz). 13C NMR (CDCl3), delta: 21.2, 22.5, 32.8, 43.6, 45.4, 51.4, 52.1, 107.6, 108.1, 117.5, 122.1, 122.8 (d, CPy(4), 2JC,F = 18 Hz); 125.9, 128.0, 132.5, 134.0, 135.6 (d, CPy(3), 3JC,F = 3 Hz); 136.1 (d, CPy(6), 2JC,F = 23 Hz); 145.5 (d, CPy(2), 3JC,F = 4 Hz); 156.4, 161.5 (d, CPy(5), 1JC,F = 257 Hz). 19F NMR (CDCl3), delta: -47.5 (d, 3JF,H = 9.1 Hz). Rf 0.46 (CHCl3-MeOH,10 : 1). Found (%): C, 74.41; H, 6.68; N, 12.79. C20H22FN3. Calculated (%): C, 74.28; H, 6.86; N, 12.99.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1133879-69-2, 3-Fluoro-5-vinylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Aksinenko, A. Yu.; Bachurin, S. O.; Maleev, G. V.; Nebogatikov, V. O.; Shevtsova, E. F.; Ustyugov, A. A.; Vasil?eva, N. A.; Vikharev, Yu. B.; Russian Chemical Bulletin; vol. 69; 4; (2020); p. 781 – 786; Izv. Akad. Nauk, Ser. Khim.; 4; (2020); p. 781 – 786,6;,
Pyridine – Wikipedia,
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