As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13534-90-2, name is 3,4-Dibromopyridine, molecular formula is C5H3Br2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C5H3Br2N
Aniline (86 mg, 0.929 mmol, 1.1 equiv.) was added to a pressure tube that was charged with 3,4-dibromopyridine 1 (200 mg, 0.844 mmol, 1 equiv.), Pd(OAc)2 (9 mg, 42 mumol, 0.05 equiv.), PPh3 (22 mg, 84 mumol, 0.1 equiv.) and sodium tert-butoxide (243 mg, 2.53 mmol, 3 equiv.) under argon. The tube was backfilled with argon several times. The degassed anhydrous toluene (7 mL) was added under argon. The reaction mixture then heated at 110 C for 5 h. After cooling, the reaction mixture was diluted with dichloromethane (10 mL), and the resulting mixture was filtered through a pad of Celite, which was washed three times with dichloromethane (30 mL). The filtrate was concentrated in vacuo. The crude product was purified by flash chromatography (silica gel; hexane/ethyl acetate, 10:1) to yield 8a (151 mg, 72%) as a colorless oil; 1H NMR (500 MHz, Chloroform-d) delta 8.48 (s, 1H), 8.13 (d, J = 5.7 Hz, 1H), 7.44 – 7.37 (m, 2H), 7.28 – 7.19 (m, 3H), 6.91 (d, J = 5.7 Hz, 1H), 6.52 (s, 1H); 13C NMR (126 MHz, Chloroform-d) delta 151.54, 148.79, 148.11, 138.47, 129.76, 125.54, 123.44, 108.39, 107.78.
With the rapid development of chemical substances, we look forward to future research findings about 13534-90-2.
Reference:
Article; Hung, Tran Quang; Hieu, Do Trung; Van Tinh, Dinh; Do, Ha Nam; Nguyen Tien, Tuan Anh; Van Do, Dang; Son, Le Thanh; Tran, Ngoc Han; Van Tuyen, Nguyen; Tan, Vu Minh; Ehlers, Peter; Dang, Tuan Thanh; Langer, Peter; Tetrahedron; vol. 75; 40; (2019);,
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