Introduction of a new synthetic route about 4-Bromo-2-isopropoxypyridine

The chemical industry reduces the impact on the environment during synthesis 1142194-24-8, I believe this compound will play a more active role in future production and life.

Application of 1142194-24-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1142194-24-8, name is 4-Bromo-2-isopropoxypyridine, molecular formula is C8H10BrNO, molecular weight is 216.08, as common compound, the synthetic route is as follows.

General procedure: To 1.76 mmol of the appropriate amine in 10 mL dioxane are added 1.76 mmol pyridyl halide, 7.02 mmol NaOtBu, 0.70 mmol 2-(di-tert-butylphosphino)biphenyl and 0.18 mmol Pd2(dba)3. The mixture is degassed thoroughly and stirred at 45 C over night. The reaction mixture is filtered, the solvent removed in vacuo and the residue is purified by HPLC.

The chemical industry reduces the impact on the environment during synthesis 1142194-24-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/114578; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem