Reference of 1151989-04-6 ,Some common heterocyclic compound, 1151989-04-6, molecular formula is C19H14N2O5S2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of Compound 11:Aleclon hemifumarate (121 mg, 0.22 mmol, 1 eq) at room temperature in the darkDissolved in dry dimethylformamide (4 mL),Triethylamine (34 mg, 46 muL, 0.33 mmol, 1.5 eq) was added slowlyStir for half an hour,Compound 8 (95 mg, 0.23 mmol, 1.05 eq) and then slowly addedTrace of 4-dimethylaminopyridine in dimethylformamide(2mL) solution,The mixture was stirred at room temperature under an argon atmosphere overnight. The solvent is removed under reduced pressure and subjected to rapid preparative column chromatography.One-step purification (methanol: methylene chloride, 1/50 to 1/10 v/v) afforded white solid (yield: 67 mg, 37%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1151989-04-6, its application will become more common.
Reference:
Patent; Fudan University; Sun Tao; Jiang Chen; (22 pag.)CN109846824; (2019); A;,
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