Reference of 79456-33-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 79456-33-0, name is 5-Chloro-3-(trifluoromethyl)pyridin-2-amine, molecular formula is C6H4ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step B ethyl 6-chloro-8-(trifluoromethyl)imidazo[l,2-a]pyridine-2-carboxylate[0121] 5-chloro-3-(trifluoromethyl)-2-pyridinamine (3.0 g, 15 mmol) and ethyl bromopyruvate (4.27 mL, 30.5 mmol) in N,N-dimethylformamide (50 mL) were stirred at 60 0C for 3 hours. The mixture was allowed to cool and then poured into stirring iced water. The precipitate was stirred for 5 minutes, collected by filtration, washed with water, and dried under vacuum to give the title compound (3.5 g; 78%). LCMS: m/z 293, 295 (M+l).
According to the analysis of related databases, 79456-33-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; BASKARAN, Subramanian; CATALANO, John; CHONG, Pek; DICKSON, Hamilton; FANG, Jing; MAUNG, Jack; NEITZEL, Martin, Leon; PEAT, Andy; PRICE, Daniel; RAI, Roopa; ROBERTS, Christopher, Don; SHOTWELL, Brad; TAI, Vincent; ZHANG, Huichang; WO2010/91411; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem