5350-93-6 , The common heterocyclic compound, 5350-93-6, name is 6-Chloropyridin-3-amine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
b) Preparation of 5 -bromo-2-chloro-pyridine. 6-Chloro-pyridin-3-ylamine (15 g, 117 mmol) was dissolved slowly with constant stirring in 48percent HBr solution (50 mL) at r.t. and then the solution was chilled to -10 ¡ãC. A solution of sodium nitrite (8.9 g, 129 mmol) in cold water (25 mL) was added dropwise at -10 ¡ãC with constant stirring over 2 h, followed by a solution of copper (I) bromide (25 g, 176 mmol) in 48percent HBr (40 mL) dropwise. The mixture was- then stirred at r.t. until complete. The mixture was neutralised with sodium carbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over soldium sulfate and concentrated. The residue was purified by column chromatography on silica gel (60-120 mesh) eluting with 1percent ethyl acetate/petroleum ether to afford 5- bromo-2-chloro-pyridine (ll.l g, 49percent).
According to the analysis of related databases, 5350-93-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F2G LTD; WO2008/62182; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem