While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5350-93-6, 6-Chloropyridin-3-amine.
5350-93-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5350-93-6, name is 6-Chloropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.
Step 1: Preparation of ( 6-chloro-pyridin-3-yl) -carbamic acid tert-butyl ester; 6-Chloro-pyridin-3-ylamine (10.0 g) were dissolved in tert- butanol (140 mL) , di-tert-butyl dicarbonate (18.7 g) were added and the solution was stirred at 500C for 4 h. Di- tert-butyl dicarbonate (3.40 g) was added and the reaction mixture was stirred for another 8 h at 5O0C. Most of the solvent was removed in vacuum and the residue was dissolved in ethyl acetate and washed 3x with water, washed with brine, dried over magnesium sulfate and concentrated in vacuum. The residue was purified by column chromatography (silica 60, chloroform/ethyl acetate 10:1, Rf = 0.30) to afford 16.5 g of the title compound of the formulaas a white solid .1H-NMR (CDCl3, TMS) delta (ppm) : 1.52 (9H, s), 6.54 (IH, br s), 7.27 (IH, d, J = 3 Hz), 7.96 (IH, s), 8.23 (IH, d, J = 3 Hz) .
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5350-93-6, 6-Chloropyridin-3-amine.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2008/130021; (2008); A2;,
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