Synthetic Route of 5470-22-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-22-4, name is 4-Chloropicolinic acid. This compound has unique chemical properties. The synthetic route is as follows.
Synthesis of (56) 4-(4-benzothiazol-2-yl-phenylamino)-pyridine-2-carbogylic acid methylamide: [Show Image] Step 1: A mixture of methylamine hydrochloride (544 mg, 8.05 mmol) and 4-chloropicolinic acid (296 mg, 2.30 mmol) in DMF (5 mL) was treated with EDC*HCl (661 mg, 3.45 mmol) and DIEA (2.0 mL, 11.5 mmol) at r.t. for 40 h. was continued over night (LCMS: ST179_21h). Reaction mixture was partitioned between aq. satd NaHCO3 (50 mL) and CHCl3 (3 x 35 mL). Combined org. phases were washed with aq. satd NH4Cl (2 x 50 mL) and dried over MgSO4. The organic phase was purified by chromatography on silica gel using petroleum ether/ethyl acetate 2:1 1 to pure ethyl acetate. Product was finally purified by prep. HPLC. Product fraction was again partitioned between satd aq. NaHCO3 (20 mL) and CHCl3 (3 x 30 mL) to remove any formic acid still present from HPLC, and dried over MgSO4. Resulting oil was dried only under reduced pressure, 25 mbar, as product is volatile at high vacuum.
According to the analysis of related databases, 5470-22-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; 4SC AG; EP1746096; (2007); A1;,
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