Introduction of a new synthetic route about 553-26-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,553-26-4, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 553-26-4, 4,4′-Bipyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 553-26-4, blongs to pyridine-derivatives compound. 553-26-4

A mixture of 4,4′-bipyridyl (20 g) in water (330 mL) was hydrogenated at 5 atmospheres pressure and at 50 C. over 5% Rh-C catalyst (5.0 g). The uptake of hydrogen gas was continued until the thermatical amount of hydrogen had been absorbed. After cooling, the catalyst was removed by filtration through celite. The water was evaporated and the residue azeotroped with toluene (2¡Á100 mL). The residue was purified by chromatography on neutral alumina using a mixture of dichloromethane-methanol (98:2) as eluent to give, as a cream-coloured solid, 4-(4-pyridyl)piperazine (11.4 g): m.p. 82-84 C.: NMR (CDCl3); 1.57-1.70(qd, 2H), 1.82(m, 2h), 2.53-2.63(ttt, 1H), 2.68-2.80 (td, 2H), 3.20 (d, 2H), 7.12(d, 2H), 8.52(d, 2H); EI-MS m/z 163 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,553-26-4, its application will become more common.

Reference:
Patent; Zeneca Limited; US6391880; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem