571188-59-5, A common compound: 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate,molecular formula is C14H22N4O2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
In a 2L four-neck round bottom flask,Add 100 g of 2-chloro-4-cyclopentyl-N,N-dimethyl-7H-pyrrole[2,3-d]pyrimidine-6-carboxamide (Formula 2), 104.6 g of 4-(6-aminopyridine- 3-yl) piperazine-1-carboxylic acid tert-butyl ester (formula 1),155.8 g of cesium carbonate, after replacing three times with nitrogen, 800 g of 4-methyl-2-pentanone was added.1.534 g of palladium acetate, 6.38 g of BINAP. After the addition is completed, under a nitrogen atmosphere,The temperature was raised to 90 to 100 C and the reaction was carried out for 3 hours. Cool down to 65 C, add 800g water, 270g n-heptane,10 ml of propylenediamine, cooled to room temperature, filtered, and the filter cake was washed once with 500 g of water.Rinse once with 160g of 4-methyl-2-pentanone/270g of n-heptane mixed solvent.Drying at 60 C gives 4-(6-(7-cyclopentyl-6-(dimethylaminoformyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)aminopyridin-3-yl Piperazine-1-carboxylic acid tert-butyl ester) (Formula 3) 168 g. The yield is 92.2%.Determined by HPLC (area normalization method),4-(6-(7-Cyclopentyl-6-(dimethylaminoformyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)aminopyridin-3-yl)piperidyl The purity of the tert-butyl ester of azine-1-carboxylate was 98.8%.
With the rapid development of chemical substances, we look forward to future research findings about 571188-59-5.
Reference:
Patent; Chongqing San Sheng Industrial Co., Ltd.; Wu Ke; He Wei; Peng Lei; Wang Longlin; Jiang Guangding; Yang Fan; (7 pag.)CN109400612; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem