Introduction of a new synthetic route about 58530-53-3

Statistics shows that 58530-53-3 is playing an increasingly important role. we look forward to future research findings about 2,4-Dibromopyridine.

Electric Literature of 58530-53-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58530-53-3, name is 2,4-Dibromopyridine, molecular formula is C5H3Br2N, molecular weight is 236.892, as common compound, the synthetic route is as follows.

A mixture of the bororate C2 (500 mg, 0.643 mmol), 2,4-dibromopyridine (152 mg, 0.643 mmol), tetrakis(triphenylphosphine) palladium (0) (52 mg, 0.045 mmol), 2 M Na2CO3(aq) (0.8 cm3), EtOH (0.8 cm3) and toluene (2 cm3) was degassed and then heated at reflux with a bath temperature of 110 C under argon for 45 h. The mixture was allowed to cool. The two phases were separated. The aqueous layer was extracted with ether (3×4 cm3). The organic layer and the ether extracts were combined, washed with brine (1×7 cm3) and dried over anhydrous sodium sulfate and the solvents were completely removed. Purification by column chromatography over silica gel using DCM-light petroleum (0:1 to 1:0) as eluent gave 140 mg (27%) ofC-3 as a light brown solid; deltaH(200 MHz; CDCl3) 0.82-1.07 (12 H, m, Me), 1.23-1.68 (16 H, m, CH2); 1.69-1.88 (2 H, m, CH), 3.93 (4 H, m, ArOCH2), 7.04 (4 H, m, ArH), 7.43-7.83 (11 H, m, CarH & ArH), 7.97 (1 H, m, PyH), 8.11(1 H, m, PyH), 8.36 ((2 H, m, CarH), and 8.54 (1 H, m, PyH); m/z [APCI+] 805, 806, 807, 808, 809 (M+).

Statistics shows that 58530-53-3 is playing an increasingly important role. we look forward to future research findings about 2,4-Dibromopyridine.

Reference:
Patent; ISIS INNOVATION LIMITED; THE UNIVERSITY COURT OF THE UNIVERSTIY OF ST ANDREWS; WO2004/20448; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem