Adding a certain compound to certain chemical reactions, such as: 1150617-54-1, 6-Bromo-1H-pyrazolo[4,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 6-Bromo-1H-pyrazolo[4,3-b]pyridine, blongs to pyridine-derivatives compound. Safety of 6-Bromo-1H-pyrazolo[4,3-b]pyridine
A solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (29) (330mg, 1.52 mmol), 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (30) (378 mg, 1.82 mmol), PdCl2(dppf)-CH2Cl2 (61.9 mg, 80 mol) and K2CO3 (628mg, 4.54 mmol) in 1,4-dioxane:water (15 mL, 2:1, v) in a microwave tube was flushed with N2 for 5min then sealed. The tube was heated at 80 C for 2 h. Then the reaction mixture was evaporated todryness. The residue was purified by flash chromatography to give 31 (260 mg, 86% yield); LC-MSm/z (ESI) found (M + H)+ 200.0 (M + H)+; 1H-NMR (400 MHz, DMSO-d6) delta13.29 (s, 1H), 8.80 (s, 1H),8.36 (s, 1H), 8.24 (s, 1H), 8.07 (s, 2H), 3.90 (s, 3 H).
The synthetic route of 1150617-54-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Yan; Liu, Hongchun; Zhang, Zhen; Wang, Ruifeng; Liu, Tongchao; Wang, Chaoyun; Ma, Yuchi; Ai, Jing; Zhao, Dongmei; Shen, Jingkang; Xiong, Bing; Molecules; vol. 22; 4; (2017);,
Pyridine – Wikipedia,
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