Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 126325-47-1, name is 6-Bromo-2-methylpyridin-3-amine. A new synthetic method of this compound is introduced below., SDS of cas: 126325-47-1
A solution of 6-bromo-2-methylpyridin-3-amine (24 g, 128 mmol) and AcOH (14.7 mL 257 mmol) in MeOH (200 mL) was cooled to 0C, Br2 (36.9 g, 230.9 mmol, 11.9 mL) was added and stirred at 0C for 5 hours. The mixture was quenched with saturated aqueous Na2S03 (500 mL), extracted with ethyl acetate (300 mL x 3). The organic layer was washed with brine (200 mL), dried over Na2S04, and concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ethenethyl acetate = 2:1) to afford 4,6-dibromo-2-methylpyridin-3-amine.
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Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; MARIGO, Mauro; (142 pag.)WO2019/121840; (2019); A1;,
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