The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H6ClNO3
To a solution of the intermediate of step 3 (2.7 g, 14.4 mmol) in CH2Cl2 (75 mL) were added DIPEA (7.53 mL, 43.3 mmol) and HATU (5.49 g, 14.4 mmol) at 0 C. and RM was stirred for 15 min. O,N-Dimethyl-hydroxylamine hydrochloride (1.41 g, 14.4 mmol) was added at 0 C. and the RM was stirred at RT for 14 h. The RM was diluted with CH2Cl2 and was consecutively washed with water, sat. NaHCO3, sat. NH4Cl and brine. The organic layer was dried and the volatiles were removed under reduced pressure. The residue was purified by chromatography (SiO2, EtOAc/Hex) to yield the desired compound (3.1 g, 93%). [0353] LC-MS (Method 3): m/z [M+H]+=231.1 (MW calc.=230.65); Rt=2.61 min.
With the rapid development of chemical substances, we look forward to future research findings about 716362-10-6.
Reference:
Patent; GRUeNENTHAL GMBH; VOSS, FELIX; NORDHOFF, SONJA; WACHTEN, SEBASTIAN; WELBERS, ANDRE; RITTER, STEFANIE; US2015/166505; (2015); A1;,
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