As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60010-03-9, name is 2,6-Dichloro-4-methyl-3-nitropyridine, molecular formula is C6H4Cl2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2,6-Dichloro-4-methyl-3-nitropyridine
Cyclopropylmethylamine (8.4 mmol, 0.72 mL, ) was added drop-wise to a solution of 3-nitro-2,6- dichloropyridine (-4.8 mmol, 1.32 g at -75% purity) in THF (10 mL) . The resulting solution was stirred at room temperature for 18 hours. Additional (1272) cyclopropylmethylamine (2.7 mmol, 0.23 mL) was added and the reaction mixture was stirred for 18 hours. The yellow suspension was diluted with ethyl acetate and the solution was washed with saturated sodium hydrogen carbonate solution, dried ( gS04) and evaporated to afford the crude title compound as yellow oil (1.35 g) which was used without further purification.
With the rapid development of chemical substances, we look forward to future research findings about 60010-03-9.
Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem