Introduction of a new synthetic route about 626-64-2

Statistics shows that 626-64-2 is playing an increasingly important role. we look forward to future research findings about Pyridin-4-ol.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-64-2, name is Pyridin-4-ol, the common compound, a new synthetic route is introduced below. 626-64-2

Al.l 4-Etaydroxypyridine ( 40.Og, 0.42 mol ) was added portionwise to fuming nitric acid (140 ml) and sulfuric acid (500ml). The resulting mixture was heated to 1400C for 12 hours. The reaction mixture was cooled in an ice-bath and cautiously poured onto ice (500ml). The yellow solid which precipitated was collected by filtration and dried under vacuum to yield Al.l ( 70.Og, 90%). 1H-NMR ( DMSO-d6) 6: 4.06 ( 2H, s). HPLC (B): 98.9%, ret. time = 0.173 min., LC/MS (M-H)+ = 184.

Statistics shows that 626-64-2 is playing an increasingly important role. we look forward to future research findings about Pyridin-4-ol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/53166; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem