Adding a certain compound to certain chemical reactions, such as: 70298-88-3, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, blongs to pyridine-derivatives compound. Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide
Step 2 To a solution of 2,2-dimethyl-N-pyridin-3-yl-propionamide (3.0 g, 17.0 mmol) in dry THF (50 mL) was added t-BuLi in pentanes (28.0 mL, 1.5 M in pentanes) dropwise at -78 C. After the addition, the reaction was stirred at -50 C. for 1 hr. Then benzaldehyde (2.17 g, 20.5 mmol) was added at -78 C. The mixture was allowed to warm to room temperature and stirred overnight. The mixture was quenched with chilly saturated NH4Cl (60 mL) and extracted with EA (60 mL*3). The organic layers were washed with brine (100 mL), dried over anhydrous Na2SO4 and concentrated to give crude product, which was purified by silica gel column (PE) to afford N-[4-(hydroxy-phenyl-methyl)-pyridin-3-yl]-2,2-dimethyl-propionamide (1.60 g, yield: 33%) as a yellow solid. 1H NMR (300 MHz , CDCl3): delta=9.34 (s, 1H), 8.73 (brs, 1H), 8.25 (d, J=4.8 Hz, 1H), 7.36-7.28 (m, 5H), 7.05 (d, J=5.2 Hz, 1H), 5.89 (s, 1H), 1.31 (s, 9H) .
The synthetic route of 70298-88-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sanford-Burnham Medical Research Institute; The Royal Institution for the Advancement of Learning / McGill University; The Government of the United States of America as Represented by the Secretary of the Department of; RONAI, Ze’ev; PINKERTON, Anthony B.; FENG, Yongmei; TOPISIROVIC, Ivan; BROWN, Kevin; HASSIG, Christian A.; (155 pag.)US2018/44324; (2018); A1;,
Pyridine – Wikipedia,
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