Reference of 957187-27-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 957187-27-8, name is 8-Bromo-6-chloroimidazo[1,2-a]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
Step B: 2′-Amino-r,2,2-trimethyl-6-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)spiro[chroman-4,4′- imidazol]-5′(l’H)-one (50 mg, 0.13 mmol; see Example 103, Step A) and 8-bromo-6-chloroimidazo[l,2- ajpyridine (60 mg, 0.26 mmol) were diluted with dioxane (1 mL), followed by the addition of Pd(PPh3)4 (7.5 mg, 0.0065 mmol) and Na2C03 (324 mu, 0.65 mmol). The reaction was sealed, heated to 85C and stirred for 12 hours. The reaction was loaded directly onto silica gel and eluted with 1-10% methanol/DCM (1% Nu¾OmicronEta) to afford 2′-amino-6-(6-chloroimidazo[l,2-a]pyridin-8-yl)-l’,2,2- trimethylspiro[chroman-4,4′-imidazol]-5′(rH)-one (18 mg, 0.044 mmol, 34% yield), m/z (APCI-pos) M+l = 410.2
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 957187-27-8, 8-Bromo-6-chloroimidazo[1,2-a]pyridine.
Reference:
Patent; ARRAY BIOPHARMA INC.; HUNT, Kevin, W.; RIZZI, James, P.; COOK, Adam; WO2011/72064; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem