Application of 80194-68-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 80194-68-9, name is 3-Chloro-5-(trifluoromethyl)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: General procedure for preparing intermediates 3. As shown in scheme 1, to a solution of 3-chloro-5-(trifluoromethyl)picolinicacid 1 (0.5 g, 2.22 mmol) in 5 mL ofacetonitrile, pyridine (0.7 g, 8.87 mmol) and methanesulphonyl chloride (0.51 g,4.43 mmol) was slowly added at -5 0C, and was left to stir at -5 0Cfor 10 min. The corresponding substituted 2-amino-benzoic acid (2.22 mmol) wasadded and left to stir for further 10 min. Pyridine (0.7 g, 8.87 mmol) and methanesulphonylchloride (0.51 g, 4.43 mmol) were slowly added again below 0 0C. Theresulting mixture was stirred at room temperature for 10 h and monitored byTLC. After the completion of reaction above, water (5 mL) was added to themixture to afford a crystalline solid (intermediate 3) via filter and recrystallization from ethanol.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 80194-68-9, 3-Chloro-5-(trifluoromethyl)picolinic acid.
Reference:
Article; Luo, Dexia; Guo, Shengxin; He, Feng; Wang, Heying; Xu, Fangzhou; Dai, Ali; Zhang, Renfeng; Wu, Jian; Bioorganic and Medicinal Chemistry Letters; vol. 30; 3; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem