Introduction of a new synthetic route about 915006-52-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 915006-52-9, 6-Bromo-2-iodopyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Application of 915006-52-9 ,Some common heterocyclic compound, 915006-52-9, molecular formula is C5H4BrIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

15.5 g 6-Bromo-2-iodo-pyridin-3-ylamine, 5.9 ml ethyl acrylate, 2.72 g triphenylphosphine and 28.75 ml triethylamine were dissolved in 90 ml acetonitrile. An argon stream was bubbled through the reaction mixture for 10 minutes then 2.33 g palladium(ll)acetate were added and the reaction mixture stirred at 800C. The reaction mixture was filtered hot troupgh a pad of celite then the solvent was removed in vacuo.The residue was purified by chromatography on silica gel to obtain 10.2 g (E)-3-(3-Amino-6-bromo-pyridin-2-yl)-acrylic acid ethyl ester. C10H11BrN2O2 (271.12), MS(ESI+): 273.0, 271.0 (M+H+), Rf(ethyl acetate : n- heptane = 1 :2) = 0.12.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 915006-52-9, 6-Bromo-2-iodopyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANOFI-AVENTIS; WO2009/149820; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem