The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 944937-53-5, name is 6-Bromo-1H-pyrrolo[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 6-Bromo-1H-pyrrolo[3,2-b]pyridine
To a soution of 6-bromo-1 H-pyrroo[3,2-b]pyridine (300 mg, 1.5 mmo) inDMF (2 mL), at 0 C, was added NaH (183 mg, 4.6 mmoL 60% dispersion in oi?). The reaction mixture was warmed to room temperature and stirred for 10 minutes and then cooed to 0 C and 3-(choromethy 5-methyisoxazoe (240 mg, 1.8 mmo) was added. The mixture was stirred at 0 C for 10 minutes then warmed to room temperature and stirred for 4 hours. Water was addedand the reaction mixture was extracted with EtOAc. The combined organicayers were dried (MgSO4), fi[tered and evaporated. Purification (FCC, Si02,0-100% EtOAc in hexanes) gave the tiUe compound (407 mg, 92%). 1H NMR(400 MHz, DMSO-d6) oe 8.41 (d, J = 2.0 Hz, I H), 8.26 (dd, J = 2.0, 0.9 Hz, I H),7.78 (d, J = 3.4 Hz, I H), 6.64 (dd, J = 3.3, 1.0 Hz, I H), 6.07 (d, J = 1.0 Hz,1 H), 5.52 (s, 2H), 2.33 (d, J = 0.9 Hz, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 944937-53-5.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHROVIAN, Christa C.; LETAVIC, Michael A.; RECH, Jason C.; SOYODE-JOHNSON, Akinola; WALL, Jessica L.; (533 pag.)WO2017/7938; (2017); A1;,
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