Adding a certain compound to certain chemical reactions, such as: 98027-36-2, 3-Amino-5-chloro-2-hydroxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 98027-36-2, blongs to pyridine-derivatives compound. Recommanded Product: 98027-36-2
(Reference Example 8-2) To a 1,2-dichloroethane suspension (177 ml) of 3-amino-5-chloropyridin-2-ol (8.85 g) and tert-butyl 4-oxopiperidine-1-carboxylate (24.4 g) was added sodium triacetoxyborohydride (26.0 g), followed by stirring under heating at reflux for 4 hours. Tert-butyl 4-oxopiperidine-1-carboxylate (12.4 g) and sodium triacetoxyborohydride (13.7 g) were further added, and stirred under heating at reflux for 2 hours. After the reaction solution was brought back to room temperature, water and dichloromethane were added, and the solution was separated. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford tert-butyl 4-[(5-chloro-2-hydroxypiperidin-3-yl)amino]piperidine-1-carboxylate (12.7 g). 1H NMR (400 MHz, CDCl3) delta 1.43-1.50 (m, 2H), 1.47 (s, 9H), 2.00-2.03 (m, 2H), 2.95-3.01 (m, 2H), 3.32-3.35 (m, 1H), 4.03-4.06 (m, 2H), 4.98-5.00 (m, 1H), 6.25 (d, 1H, J = 2.4 Hz), 6.71 (d, 1H, J = 2.4 Hz), 12.37 (br s, 1H).
The synthetic route of 98027-36-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Daiichi Sankyo Company, Limited; EP2471792; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem