Introduction of a new synthetic route about Ethyl imidazo[1,5-a]pyridine-3-carboxylate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81803-60-3, its application will become more common.

Reference of 81803-60-3 ,Some common heterocyclic compound, 81803-60-3, molecular formula is C10H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To an ice cold solution of ethyl imidazo[l,5-alpha]pyridine-3-carboxylate (10 g, 52.6 mmol) in acetonitrile (500 mL) was added N-bromo succinimide (9.36 g, 52.6 mmol). The mixture was allowed to stir for 1 h at which time triethylamine (10 mL) was added to the deep red- violet solution. The color dissipated and the solution was concentrated. Purification of the crude solid by silica gel chromatography (0-20% EtOAc/Hexanes) provided a white crystalline solid (13.5 g 95%). MS 268.9 (M + 1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81803-60-3, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2008/85302; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem