Related Products of 64951-08-2, Adding some certain compound to certain chemical reactions, such as: 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid,molecular formula is C8H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64951-08-2.
A mixture of 3-(cis-4-aminocyclohexyl)-6-fluoro-l-(tetrahydro-2H-thiopyran-4- yl)pyrido[2,3-d]pyrimidine-2,4(lH,3H)-dione hydrochloride (600 mg, 1.5 mmol), imidazo[l52-a]pyridme-2-carboxylic acid (292 mg, 1.8 mmol), HATU (685 mg, 1.8 mmol), and DIEA (1.02 ml, 6 mmol) in nuMP (80 ml) was stirred for 1 h at room temperature (at pH 8-9). Ethyl acetate was added and the crude product was washed twice with aqueous sodium hydrogencarbonate, 0.5 M aqueous citric acid and water. The organic solvents dried over nua2SO4, filtrated and removed in vacuum. The residue was recrystallised in ethyl acetate (5 ml) to give the title compound (750 mg, 96%). 1H nuMR (400 MHz, DMSCW6): delta 8.79 (IH, d); 8.68 (IH, d); 8.52 (IH, s); 8.25(IH, dd); 7.94 (IH, brs); 7.75 (IH, d); 7.49 (IH, t); 7.10 (IH, t); 5.22 (IH, brs); 4.84 (IH, t); 4.16 (IH, s); 2.84-2.69 (6H, m); 2.61 (2H, q); 1.99 (4H, m); 1.71 (2H, t); 1.57 (2H, brd) APCI-MS m/z: 523 [MH+].
According to the analysis of related databases, 64951-08-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; WO2007/108750; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem