Related Products of 69950-65-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 69950-65-8 as follows.
To methyl 5-formylpicolinate (1.0 g, 6.055 nimol) dissolved in ethanol-water (14.4 mL, 2: 1 ) was added hydroxylamine hydrochloride (0.463 g, 6.66 mmol) and sodium acetate (0.546 mg, 0.6661 mmol). The reaction mixture was stirred overnight at 55 C. The reaction was concentrated under reduced pressure and redissolved in EtOAc (100 mL). The organic phase was washed with water, dried over sodium sulfate, filtered and concentrated under reduced pressure. The solid residue was dissolved triturated with EtOAc, filtered and dried under reduced pressure affording methyl 6-(hydroxyimino)methyl)picoiinate (990 mg, 5.495 mmol, 91 %) as a beige solid. LCMS [M+H]+: 181.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69950-65-8, its application will become more common.
Reference:
Patent; ARQULE, INC.; BATES, Craig; EATHIRAJ, Sudharshan; INAGAKI, Hiroaki; LAPIERRE, Jean-Marc; MOMOSE, Takayuki; NAKAYAMA, Kiyoshi; ODAGIRI, Takashi; OTA, Masahiro; OTA, Yusuke; SHIBATA, Yoshihiro; TANDON, Manish; TSUNEMI, Tomoyuki; (371 pag.)WO2018/39310; (2018); A1;,
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