Adding a certain compound to certain chemical reactions, such as: 39977-44-1, Methyl 6-(hydroxymethyl)picolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Methyl 6-(hydroxymethyl)picolinate, blongs to pyridine-derivatives compound. Application In Synthesis of Methyl 6-(hydroxymethyl)picolinate
EXAMPLE 18 Preparation of 6-formylpyridine-2-carboxylic Acid Methyl Ester (IVo) A solution of 3 g of 6-hydroxymethylpyridine-2-carboxylic acid methyl ester (16.5 mmol) in 70 ml of 1,2-dichloroethane containing 15 g of manganese dioxide (165 mmol) is heated under reflux for 4 hours with removal of the water formed continuously. The solid is removed by filtration on celite and then the dichloromethane is evaporated off. The title product is isolated by chromatography on a silica column (eluent: dichloromethane/ethyl acetate; 70:30). 2.33 g of a yellow oil are recovered. Yield: 79% 1 H NMR (CDCl3) delta: 1.36 (t, 3H); 4.41 (m, 2H); 8.13 (dd, 1H); 8.24 (t, 1H); 8.32 (dd, 1H); 10.02 (s, 1H). IR (film) ?: 1700 cm-1 (C=O).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,39977-44-1, Methyl 6-(hydroxymethyl)picolinate, and friends who are interested can also refer to it.
Reference:
Patent; Pierre Fabre Medicament; US6020345; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem