Related Products of 6221-01-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6221-01-8, name is Pyridine-2,5-dicarbaldehyde. A new synthetic method of this compound is introduced below.
General procedure: To a stirred solution of 2,5-pyridinedicarboxaldehyde(0.37 mmol) in 5 mL EtOH was added the indole (1.85 mmol) andI2 (0.15 mmol). The resulting mixture was stirred at reflux for 6 hcooled and treated with aqueous Na2S2O3. The combined organiclayers obtained by extraction with EA (3 30 mL) were washedwith H2O (2 10 mL) and brine (2 10 mL), dried over MgSO4 and concentrated under reduced pressure to give a residue, which wassubjected to flash column chromatography, followed by normalphaseHPLC to afford the pure product. 4.3.2 3,3′,3″,3?-(Pyridine-2,5-diylbis(methanetriyl))tetrakis(1H-indole) (3a) Yield 50% (white powder), mp 164-165 C, 1H NMR (400 MHz, DMSO-d6): delta 10.85 (s, 2H, NH), 10.81 (s, 2H, NH), 8.51 (s, 1H, ArH), 7.59 (d, J = 8.4 Hz, 1H, ArH), 7.35-7.25 (m, 9H, ArH), 7.05-7.00 (m, 4H, ArH), 6.90 (s, 2H, ArH), 6.87-6.83 (m, 6H, ArH), 5.89 (s, 1H, CH), 5.86 (s, 1H, CH). 13C NMR (100 MHz, DMSO-d6): delta 162.48, 149.53, 138.42, 137.51, 137.36, 136.97, 127.65, 127.36, 124.49, 124.42, 122.88, 121.90, 121.74, 119.92, 119.20, 119.12, 118.32, 118.05, 112.45, 112.35, 43.21, 37.74. HRMS calcd for C39H30N5 (M + H)+, 568.2501; found, 568.2500.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6221-01-8, its application will become more common.
Reference:
Article; Fu, Chih-Wei; Hsieh, Yun-Jung; Chang, Tzu Ting; Chen, Chia-Ling; Yang, Cheng-Yu; Liao, Anne; Hsiao, Pei-Wen; Li, Wen-Shan; European Journal of Medicinal Chemistry; vol. 104; (2015); p. 165 – 176;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem