The reactivity of isocyanides with pentafluoropyridine was written by Irani, Motahereh;Ranjbar-Karimi, Reza;Poorfreidoni, Alireza;Mehrabi, Hossein. And the article was included in Monatshefte fuer Chemie in 2021.Electric Literature of C5F5N The following contents are mentioned in the article:
Reactivity of some isocyanides with pentafluoropyridine under basic conditions in dry DMSO was investigated. The reaction of pentafluoropyridine with toluenesulfonylmethyl isocyanide (TosMIC) was less selective, but the reactions of other isocyanides with pentafluoropyridine gave the desired 2,3,5,6-tetrafluoro-N-substituted isonicotinamide. The structures of all the compounds were confirmed by IR, 1H NMR, 19F NMR, and 13C NMR spectroscopy, X-ray crystallog. as well as elemental anal. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Electric Literature of C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the è?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the è?bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C5F5N