Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors was written by Ishida, Hiroshi;Isami, Shoichi;Matsumura, Tsutomu;Umehara, Hiroshi;Yamashita, Yoshinori;Kajita, Jiro;Fuse, Eiichi;Kiyoi, Hitoshi;Naoe, Tomoki;Akinaga, Shiro;Shiotsu, Yukimasa;Arai, Hitoshi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.SDS of cas: 625438-03-1 The following contents are mentioned in the article:
5-(1,3,4-Oxadiazol-2-yl)pyrimidine derivative 1 was identified as a new class of FLT3 inhibitor from our compound library. With the aim of enhancement of antitumor activity of 2 prepared by minor modification of 1, structure optimization of side chains at the 2-, 4-, and 5-positions of the pyrimidine ring of 2 was performed to improve the metabolic stability. Introduction of polar substituents on the 1,3,4-oxadiazolyl group contributed to a significant increase in the metabolic stability. As a result, a series of compounds showed increased efficacy against MOLM-13 xenograft model in mice by oral administration. This study involved multiple reactions and reactants, such as 2-(2-Methylpyridin-4-yl)ethanamine (cas: 625438-03-1SDS of cas: 625438-03-1).
2-(2-Methylpyridin-4-yl)ethanamine (cas: 625438-03-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of é?8.7 è?10é? cm3è·¯molé?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJè·¯molé? in the liquid phase and 140.4 kJè·¯molé? in the gas phase. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 625438-03-1