Ismael, Aya; Gevorgyan, Ashot; Skrydstrup, Troels; Bayer, Annette published the artcile< Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions>, Related Products of 93-60-7, the main research area is aryl bromide boronic acid palladium renewable solvent carbonylative coupling; ketone aryl preparation; amine aryl bromide palladium renewable solvent aminocarbonylation catalyst; amide preparation; alkoxide aryl bromide palladium renewable solvent alkoxycarbonylation catalyst; ester preparation.
Solvents constitute the largest component for many chem. processes and substitution of nonrenewable solvents is a longstanding goal for green chem. Here, we show that Pd-catalyzed carbonylative couplings, such as carbonylative cross-couplings, aminocarbonylations, and alkoxycarbonylations, can be successfully realized using renewable solvents. The present research covers not only well-established renewable solvents, such as 2-methyltetrahydrofuran (2MeTHF), limonene, and di-Me carbonate, but also recently introduced biomass-derived 1,1-diethoxyethane, isosorbide di-Me ether, eucalyptol, rose oxide, γ-terpinene, and α-pinene. The carbonylative coupling of boronic acids and aryl bromides works well in limonene. Aminocarbonylation gave excellent results in di-Me carbonate, α-pinene, and limonene, while alkoxycarbonylation was successful in 2MeTHF, α-pinene, γ-terpinene, and di-Me carbonate. The developed methods based on renewable solvents can be used for the synthesis of com. drug Trimetozine and an analog of Itopride.
Organic Process Research & Development published new progress about Alkoxycarbonylation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.