Jacobs, Kelly R.’s team published research in Neurobiology of Aging in 2019 | CAS: 98-98-6

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.HPLC of Formula: 98-98-6

In 2019,Neurobiology of Aging included an article by Jacobs, Kelly R.; Lim, Chai K.; Blennow, Kaj; Zetterberg, Henrik; Chatterjee, Pratishtha; Martins, Ralph N.; Brew, Bruce J.; Guillemin, Gilles J.; Lovejoy, David B.. HPLC of Formula: 98-98-6. The article was titled 《Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer’s disease and relationship to amyloid-β and tau》. The information in the text is summarized as follows:

Chronic kynurenine pathway (KP) activation is implicated in Alzheimer’s disease (AD) pathophysiol. and results in quinolinic acid-induced excitotoxic stimulation of the N-methyl-D-aspartate receptor. However, most studies focus on plasma and it is unclear if peripheral concentrations reflect brain concentrations and how these may correlate to the AD biomarkers amyloid-β, total-tau (t-tau), or phosphorylated-tau (p-tau). We characterized the KP in matched plasma and cerebrospinal fluid (CSF) samples from 20 AD patients and 18 age-matched control subjects. Plasma concentrations of kynurenine (KYN), 3-hydroxykynurenine, anthranilic acid, picolinic acid, and neopterin significantly correlated with their resp. CSF levels. In patients with AD, plasma KYN (r = -0.48, p = 0.033) and picolinic acid (r = -0.57, p = 0.009) inversely correlated with CSF p-tau and t-tau, resp. Furthermore, in AD CSF, increased 3-hydroxykynurenine/KYN ratio correlated with t-tau (r = 0.58, p = 0.009) and p-tau (r = 0.52, p = 0.020). These data support KP involvement in AD pathogenesis and add to the case for the therapeutic modulation of the KP in AD. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6HPLC of Formula: 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.HPLC of Formula: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem