Jeon, So Mi; Lim, Je Sun; Kim, Hyung-Ryong; Lee, Jong-Ho published the artcile< PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells>, Electric Literature of 123-03-5, the main research area is human dental pulp stem cell odontogenic differentiation PFK activation; Aerobic glycolysis; Differentiation; Human dental pulp stem cell; Odontoblast; PFK.
Dental pulp stem cells (DPSCs) can differentiate into diverse cell lineages, including odontogenic cells that are responsible for dentin formation, which is important in pulp repair and tooth regeneration. While glycolysis plays a central role in various cellular activities in both physiol. and pathol. conditions, its role and regulation in odontogenic differentiation are unknown. Here, we show that aerobic glycolysis is induced during odontoblastic differentiation from human DPSCs. Importantly, we demonstrate that during odontoblastic differentiation, protein expression levels of phosphofructokinase 1 muscle isoform (PFKM) and PFK2, but not other glycolytic enzymes, are mainly upregulated by AKT activation, resulting in increased total PFK enzyme activity. Increased PFK activity is essential to enhance aerobic glycolysis, which plays an important role in the odontoblastic differentiation of human DPSCs. These findings underscore that PFK activation-induced aerobic glycolysis accompanies, and participates in, human DPSCs differentiation into odontogenic lineage, and could play a role in the regulation of dental pulp repair.
Biochemical and Biophysical Research Communications published new progress about Dental pulp. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.