Safety of 4-EthynylpyridineIn 2022 ,《Study on “”Click”” assembly of novel dual inhibitors of AChE and MAO-B from pyridoxine derivatives for the treatment of Alzheimer’s disease》 appeared in Heterocyclic Communications. The author of the article were Jia, Zhao; Wen, Huiyun; Huang, Saipeng; Luo, Yane; Gao, Juanjuan; Wang, Ruijie; Wan, Kaikai; Xue, Weiming. The article conveys some information:
This study fast synthesizes numerous functionalized pyridoxines I [R = Ph, 4-fluorophenyl, 3-aminophenyl, etc.] using click chem. and assayed in vitro as inhibitors of the acetylcholinesterase (AChE), butyrylcholinesterase, and two monoamine oxidase (MAO) isoforms, MAO-A and MAO-B. Most of the obtained compounds demonstrated good AChE and selective MAO-B inhibitory activities in the micromolar range, especially one compound, called I [R = 3-aminophenyl], exhibits excellent inhibitory performance against AChE (IC50 = 0.0816 ± 0.075μM) and MAO-B (IC50 = 0.039 ± 0.003μM). Finally, a docking study was carried out, demonstrating potential binding orientations and interactions of the compounds in terms of the AChE and MAO-B active sites. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 4-Ethynylpyridine