Jiang, Ling published the artcileApplication of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives, Computed Properties of 72509-76-3, the main research area is aryl aldehyde acetoacetate aminocrotonate papain catalyst three component reaction; phenyl dihydropyridine dicarboxylate preparation green chem.
A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, Me acetoacetate and Et 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and eco-friendliness are the key features of this protocol.
Chemical Research in Chinese Universities published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Computed Properties of 72509-76-3.