Jiang, Ling published the artcileMechanochemical enzymatic synthesis of 1,4-dihydropyridine calcium antagonists and derivatives, Application In Synthesis of 72509-76-3, the main research area is Lipozyme ball milling dihydropyridine calcium antagonists.
BACKGROUND : Enzyme promiscuity has attracted significant attention from chemists and biochemists in recent years. However, long reaction time and use of toxic organic solvents limit its applications for industrial processes. 1,4-Dihydropyridine (1,4-DHP) calcium antagonists are recommended for the first line treatment of hypertension. Although some chem. protocols for the preparation of 1,4-DHP calcium antagonists have been developed, enzymic synthesis of these compounds still remains uncovered. RESULTS : Solvent-free quick synthesis of 1,4-DHP calcium antagonists felodipine, nitrendipine, nifedipine and nemadipine B and their derivatives was achieved by Lipozyme RM IM (triacylglycerol acylhydrolase, EC3.1.1.3)-catalyzed multicomponent reactions of aromatic aldehyde, alkyl acetoacetate and alkyl 3-aminocrotonate under ball-milling conditions. The products were obtained in moderate yields (up to 86.8%) and the influence of reaction conditions including catalyst loading, grinding auxiliary and grinding frequency was investigated. CONCLUSION : The protocol successfully overcame some longstanding problems in the field of enzymic promiscuity research, such as long reaction time and use of harmful organic solvents, and demonstrated the potential application value of promiscuous enzyme-catalyzed reactions under ball-milling conditions for pharmaceutical synthesis. © 2019 Society of Chem. Industry.
Journal of Chemical Technology and Biotechnology published new progress about Pharmaceutical natural products (1,4-Dihydropyridine calcium). 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application In Synthesis of 72509-76-3.