Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors was written by Jiang, Rong;Frackowiak, Bozena;Shin, Youseung;Song, Xinyi;Chen, Weimin;Lin, Li;Cameron, Michael D.;Duckett, Derek R.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Product Details of 89978-52-9 This article mentions the following:
Starting from a pyrazole HTS (high throughput screening) hit, a series of 1-aryl-1H-indazoles have been synthesized as JNK3 inhibitors with moderate selectivity against JNK1. SAR studies led to the synthesis of a double digital nanomolar JNK3 inhibitor (I) with good in vivo exposure. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Product Details of 89978-52-9).
Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 89978-52-9