In 2022,Jiang, Ting; Cao, Ya-Nan; Xu, Jin-Bu; Gao, Feng; Zheng, Ling-Li published an article in Scientific Reports. The title of the article was 《Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids》.Name: 2-Bromo-5-methylpyridine The author mentioned the following in the article:
A series of new paclitaxel-benzoxazoles hybrids I (R = Ph, 2-naphthyl, 3-pyridyl, etc.; R1 = O-tert-Bu, Ph) were designed based on both the mol. docking mode of beta-tubulin with paclitaxel derivatives I (R = Ph, 3-pyridyl; R1 = Ph), and the activity-structure relationship of C-13 side chain in paclitaxel. Palladium-catalyzed direct Csp2-H arylation of benzoxazoles with different aryl-bromides was used as the key synthetic strategy for the aryl-benzoxazoles moieties in the hybrids. Twenty-six newly synthesized hybrids were screened for their antiproliferative activity against human cancer cell lines such as human breast cancer cells (MDA-MB-231) and liver hepatocellular cells (HepG2) by the MTT assay and results were compared with paclitaxel. Interestingly, most hybrids showed significantly active against both cell lines at concentration of 50μM, which indicated that the hybrid strategy is effective to get structural simplified paclitaxel analogs with high anti-tumor activity. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Name: 2-Bromo-5-methylpyridine