《Merging C-H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis》 was written by Jiang, Xunjin; Zeng, Zhixiong; Hua, Yuhui; Xu, Beibei; Shen, Yang; Xiong, Jing; Qiu, Huijuan; Wu, Yifan; Hu, Tianhui; Zhang, Yandong. Electric Literature of C6H6BrNThis research focused onvinyl arylpyridine regioselective vinylation photochem aza electrocyclization anticancer DFT; dihydropyridoisoquinolinium preparation; dihydrobenzoquinoline preparation. The article conveys some information:
Pyridinium-containing polyheterocycles exhibit distinctive biol. properties and interesting electrochem. and optical properties and thus are widely used as drugs, functional materials, and photocatalysts. Here, we describe a unified two-step strategy by merging Rh-catalyzed C-H vinylation with two switchable electrocyclizations, including aza-6π-electrocyclization and all-carbon-6π-electrocyclization, for rapid and divergent access to dihydropyridoisoquinoliniums and dihydrobenzoquinolines. Through computation, the high selectivity of aza-electrocyclization in the presence of an appropriate “”HCl”” source under either thermal conditions or photochem. conditions is shown to result from the favorable kinetics and symmetries of frontier orbitals. We further demonstrated the value of this protocol by the synthesis of several complex pyridinium-containing polyheterocycles, including the two alkaloids berberine and chelerythrine. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H6BrN