Jiang, Ziwen; Cui, Wei; Prasad, Priyaa; Touve, Mollie A.; Gianneschi, Nathan C.; Mager, Jesse; Thayumanavan, S. published the artcile< Bait-and-Switch Supramolecular Strategy To Generate Noncationic RNA-Polymer Complexes for RNA Delivery>, Quality Control of 2127-03-9, the main research area is RNA vector polymer.
RNA interference (RNAi) requires the intracellular delivery of RNA mols. to initiate the neutralization of targeted mRNA mols., inhibiting the expression or translation of the targeted gene. Current polymers and lipids that are used to deliver RNA mols. are generally required to be pos. charged, to achieve complexation with RNA and the cellular internalization. However, pos. surface charge has been implicated as the reason for toxicity in many of these systems. Herein, we report a novel strategy to generate noncationic RNA-polymer complexes for RNA delivery with low cytotoxicity. We use an in situ electrostatic complexation using a methylated pyridinium group, which is simultaneously removed during the RNA binding step. The resultant complexes demonstrate successful knockdown in preimplantation mammalian embryos, thus providing a new approach for nucleic acid delivery.
Biomacromolecules published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Quality Control of 2127-03-9.