In 2019,Chemical Science included an article by Jin, Bo; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H.. Safety of 5-Bromo-2-chloropyridine. The article was titled 《ppm Pd-catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors》. The information in the text is summarized as follows:
A new catalyst was developed for copper-free, Pd-catalyzed Sonogashira reactions at the sustainable ppm level of precious metal palladium under mild aqueous micellar conditions. Both the palladium pre-catalyst and ligand are com. available, bench stable, and highly cost-effective. The catalyst is applicable to reactions of both aryl- and heteroaryl bromides. A wide range of functional groups are tolerated and the aqueous reaction medium can be recycled. An application of this procedure to the synthesis of a key intermediate to an active pharmaceutical ingredient (ponatinib) is discussed. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 5-Bromo-2-chloropyridine