Jmai, Momtez; Efrit, Mohamed Lotfi; Dubreuil, Didier; Blot, Virginie; Lebreton, Jacques; M’rabet, Hedi published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 2021. The article was titled 《An efficient and simple strategy toward the synthesis of highly functionalized compounds》.Reference of 2-Bromonicotinaldehyde The article contains the following contents:
The expedient syntheses of small libraries of ((β-ethoxycarbonyl, -cyano and -acetyl)propyloxy) methylphosphonate scaffolds bearing olefin, sulfanyl, or amine functions are described. All these new derivatives are readily produced from easily available starting reagents (aldehydes, electron-poor olefins, and dialkylphosphites) following a three steps reaction sequence of condensations, SN2′-type reaction and a conjugated thia- or aza-Michael 1,4-addition with aromatic and aliphatic thiol or amine nucleophiles. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Reference of 2-Bromonicotinaldehyde