In 2015,Jornet-Molla, Veronica; Romero, Francisco M. published 《Synthesis of rigid ethynyl-bridged polytopic picolinate ligands for MOF applications》.Tetrahedron Letters published the findings.Safety of Methyl 5-bromopicolinate The information in the text is summarized as follows:
Segmented homopolytopic ligands that consist of a rigid central arylene platform, ethynylene spacers, and terminal chelating picolinate subunits have been synthesized in good yields in a two-step procedure involving a Sonogashira-type cross coupling reaction between the ester Me 5-bromopyridine-2-carboxylate and several arylacetylenes, followed by hydrolysis of the resulting Me picolinates [e.g., Me 5-bromopyridine-2-carboxylate + 1,4-diethynylbenzene followed by hydrolysis afforded ligand I]. A similar strategy has been employed for the preparation of heteroditopic ligands containing picolinate and a second non-chelating pyridine or benzoate unit. The compounds are potential candidates for organic linkers in metal-organic frameworks (MOFs). The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of Methyl 5-bromopicolinate