Josa-Cullere, Laia; Cogswell, Thomas J.; Georgiou, Irene; Jay-Smith, Morgan; Jackson, Thomas R.; Bataille, Carole J. R.; Davies, Stephen G.; Vyas, Paresh; Milne, Thomas A.; Wynne, Graham M.; Russell, Angela J. published the artcile< Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro>, Name: 3-Amino-5-bromopyridine-2-carboxylic Acid, the main research area is dihydrobenzooxazepinone preparation SAR acute myeloid leukemia pharmacokinetic; CD11b; acute myeloid leukemia; benzooxazepinones; differentiation; phenotypic screen.
A series of 1,5-dihydrobenzo[e][1,4]oxazepin-2(3H)-one hit compounds e.g. I was identified and synthesized. Herein, we report the hit validation in vitro, structure-activity relationship (SAR) studies and the pharmacokinetic profiles for selected compounds
Molecules published new progress about Acute myeloid leukemia. 870997-85-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrN2O2, Name: 3-Amino-5-bromopyridine-2-carboxylic Acid.