Kamga, Justin; Leonte, Denisa; Ambassa, Pantaleon; Mbaveng, Armelle T.; Fotso, Ghislain W.; Coman, Fana-Maria; Ngadjui, Bonaventure T.; Kuete, Victor; Zaharia, Valentin; Ngameni, Bathelemy published the artcile< Heterocycles 45.Synthesis, characterization and biological evaluation of 3-indolyl-1-pyridyl-2-propenones as anticancer agents>, Reference of 350-03-8, the main research area is acetylpyridine indolyl carbaldehyde diastereoselective Claisen Schmidt condensation; indolyl pyridyl propenone preparation antitumor cytotoxicity.
A series of seven indolyl pyridyl propenones I [R = H, Me, Et, etc.; Ar = 3-pyridyl, 4-pyridyl] were synthesized via Claisen-Schmidt condensation with 68.8-91.8% yields. All the synthesized compounds I were purified and characterized by m.ps., IR, 1H NMR, 13C NMR and HRMS. The cytotoxicity of the synthesized indolyl pyridyl propenones I and doxorubicin, used as pos. control, was determined in a panel of nine human cancer cell lines including both sensitive and drug-resistant phenotypes, as well as in normal AML12 hepatocytes. Compounds I [R = Et, allyl; Ar = 4-pyridyl] and [R = Me; Ar = 3-pyridyl] displayed half maximal inhibitory concentration (IC50) values below 100μM in all tested cancer cell lines meanwhile, other compounds displayed selective activities.
Farmacia (Bucharest, Romania) published new progress about Antitumor agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Reference of 350-03-8.